ABSTRACT
Multi drug resistant Gram positive cocci are implicated in life threatening infections, especially in critical care units. In the current study which was conducted from June 2018 to March 2019, the prevalence and antimicrobial resistance among gram positive cocci isolated from intensive care units of a tertiary care hospital has been detected . Various samples like urine, pus, body ?uids, sputum etc. were processed according to standard procedures. Total 81 gram positive cocci were isolated from 1650 samples. Maximum gram positive cocci were coagulase negative Staphylococcus followed by Staphylococcus aureus and enterococci. Coagulase negative Staphylococcus showed highest resistance to cotrimoxazole, erythromycin, ciprofioxacin, and penicillin and maximum sensitivity to gentamicin. Staphylococcus aureus showed maximum resistance to penicillin, tetracycline, co - trimoxazole and ciprofioxacin. All the isolates were sensitive to linezolid and vancomicin. Antimicrobial resistance among enterococci varied from 65% to 85%. Formation of antibiogram and strict adherence to hospital antibiotic policy is crucial to prevent spread of resistance among microorganisms.